Place an oven rack in the center of the oven.
Preheat the oven to 350 degrees F.
Butter and flour a 9- by 5- by 3-inch loaf pan. Set aside.
In a medium bowl, whisk together the flour, baking soda, salt, baking powder.
In a large bowl, beat the sugar, eggs and vanilla until blended. Add milk.
Stir in the blueberries.
Add the dry ingredients and stir just until blended.
Pour the batter into the prepared loaf pan.
Bake until a tooth pick inserted in the center of the loaf comes out clean, about 1 hour.
Cool for 15 minutes.
Remove the loaf from the pan and cool completely on a wire rack, about 2 hours.
